Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6590713 | 0.79 | PSEN1 (0.31) | ALDH1A1CHEK1 | |
| SCHEMBL6590708 | 0.77 | CHEK1 (0.30) | CHEK1 | |
| SCHEMBL7562868 | 0.76 | — | — | |
| SCHEMBL7563297 | 0.73 | PSEN1 (0.37) | LMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL7538627 | 0.72 | ALDH1A1 (0.39) | LMNAALDH1A1SMN1; SMN2GAAMMP3 | |
| SCHEMBL6589700 | 0.69 | SIGMAR1 (0.35) | ALDH1A1SMN1; SMN2MMP3CYP2D6 | |
| SCHEMBL6589694 | 0.68 | SIGMAR1 (0.34) | ALDH1A1SMN1; SMN2MMP3 | |
| SCHEMBL6607474 | 0.66 | KCNA5 (0.39) | ALDH1A1GAAMMP3 | |
| SCHEMBL7541555 | 0.66 | ALDH1A1 (0.36) | LMNAALDH1A1SMN1; SMN2POLBCYP2C19 | |
| SCHEMBL6591072 | 0.65 | PTGDR2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |