Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126923 | 0.93 | LMNA (0.54) | LMNATSHRMAPTTHRBKDM4E | |
| SCHEMBL7574097 | 0.87 | ACLY (0.51) | LMNATSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL1127093 | 0.84 | LMNA (0.63) | LMNATSHRMAPTTHRBKDM4E | |
| SCHEMBL7578595 | 0.79 | NPSR1 (0.72) | LMNATSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL7572428 | 0.78 | ALDH1A1 (0.54) | LMNATSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL31443316 | 0.78 | LMNA (0.49) | LMNATSHRMAPTTHRBKAT6A | |
| SCHEMBL7570349 | 0.77 | ALDH1A1 (0.60) | LMNAMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL399038 | 0.77 | ALDH1A1 (0.60) | LMNATSHRMAPTTHRBKDM4E | |
| SCHEMBL7572374 | 0.76 | NPSR1 (0.58) | LMNATSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL28572592 | 0.76 | MAPT (0.65) | LMNATSHRMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |