Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10616991 | 0.78 | SIGMAR1 (0.68) | OPRK1 | |
| SCHEMBL10616986 | 0.78 | SIGMAR1 (0.68) | OPRK1 | |
| SCHEMBL4283829 | 0.77 | CCR5 (0.62) | ATMKMT2AALDH1A1HPGDL3MBTL1 | |
| SCHEMBL11599130 | 0.77 | ATM (1.00) | ATMKMT2AALDH1A1ABCC1HPGD | |
| SCHEMBL8294300 | 0.77 | KMT2A (0.48) | ATMKMT2AALDH1A1ABCC1GAA | |
| SCHEMBL1783192 | 0.76 | PKM (0.46) | KMT2AALDH1A1GAACYP2D6OPRK1 | |
| SCHEMBL7507216 | 0.75 | PDE4B (0.46) | ATMKMT2AALDH1A1GAAHPGD | |
| SCHEMBL8294306 | 0.74 | DPP7 (0.52) | ATMKMT2AALDH1A1CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL1781771 | 0.74 | PKM (0.45) | KMT2AALDH1A1GAACYP2D6OPRK1 | |
| SCHEMBL7129642 | 0.73 | ALDH1A1 (0.59) | ATMKMT2AALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235789-A2 | $g(b)-AMINOACID COMPOUNDS USEFUL FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | ELI LILLY AND COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001034639-A2 | β-AMINOACID COMPOUNDS USEFUL FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | disclosed |