Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 5/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7583346 | 1.00 | NPC1 (0.40) | NPC1RAB9ATDP1MAOBMAOA | |
| SCHEMBL7576321 | 0.70 | IDO1 (0.50) | NPC1RAB9ATDP1MAOBMAOA | |
| SCHEMBL7629273 | 0.69 | MAOB (0.57) | NPC1RAB9ATDP1MAOBMAOA | |
| SCHEMBL7629265 | 0.69 | MAOB (0.57) | NPC1RAB9ATDP1MAOBMAOA | |
| SCHEMBL7573265 | 0.68 | VCP (0.40) | NPC1RAB9ATDP1MAOBMAOA | |
| SCHEMBL7573261 | 0.68 | VCP (0.40) | NPC1RAB9ATDP1MAOBMAOA | |
| SCHEMBL1907796 | 0.67 | DPEP1 (0.49) | NPC1RAB9ATDP1MAOBMAOA | |
| SCHEMBL2394174 | 0.67 | DPEP1 (0.49) | NPC1RAB9ATDP1MAOBMAOA | |
| SCHEMBL24181250 | 0.66 | VCP (0.46) | NPC1RAB9ATDP1MAOBMAOA | |
| SCHEMBL3183880 | 0.65 | MEN1 (0.49) | TDP1MAPTNPSR1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020099070-A1 | Dihydronaphthyridine potassium channel openers | ABBOTT LABORATORIES | 2002-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099070-A1 | Dihydronaphthyridine potassium channel openers | KCNH1, KCNN1, KCNJ2 | NPC1 244/4885RAB9A 1403/4885TDP1 792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.