Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13614803 | 0.82 | TP53 (0.45) | TP53TDP1ALDH1A1NFE2L2PTGS1 | |
| SCHEMBL2088615 | 0.78 | NFE2L2 (0.47) | GABRA1SIGMAR1NFE2L2PTGS1PTGS2 | |
| SCHEMBL2088613 | 0.78 | NFE2L2 (0.47) | GABRA1SIGMAR1NFE2L2PTGS1PTGS2 | |
| SCHEMBL293173 | 0.78 | ALDH1A1 (0.50) | TP53TDP1ALDH1A1PTGS1PTGS2 | |
| SCHEMBL29407001 | 0.78 | ALDH1A1 (0.50) | TP53TDP1ALDH1A1PTGS1PTGS2 | |
| SCHEMBL248639 | 0.78 | NFE2L2 (0.50) | TP53TDP1ALDH1A1NFE2L2PTGS2 | |
| SCHEMBL29662132 | 0.78 | NFE2L2 (0.50) | TP53TDP1ALDH1A1NFE2L2PTGS2 | |
| SCHEMBL336067 | 0.77 | ALDH1A1 (0.47) | TDP1GABRA1SIGMAR1ALDH1A1NFE2L2 | |
| SCHEMBL16958944 | 0.77 | GABRA1 (0.47) | GABRA1SIGMAR1NFE2L2PTGS1PTGS2 | |
| SCHEMBL9996728 | 0.77 | GABRA1 (0.44) | GABRA1SIGMAR1ALDH1A1NFE2L2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113493450-B | Ligand compound, preparation method thereof and application thereof in asymmetric reaction | 中国科学院福建物质结构研究所 | 2023-07-25 | — | — | CN | disclosed |
| US-11661397-B2 | 1,4-disubstituted imidazole derivative | Sumitomo Pharma Co., Ltd. (JP) | 2023-05-30 | — | — | US | disclosed |
| EP-4112606-A1 | AROMATIC COMPOUND AND USE THEREOF IN PREPARING ANTINEOPLASTIC DRUGS | Shanghai Zheye Biotechnology Co., Ltd. (CN) | 2023-01-04 | — | — | EP | disclosed |
| CN-113493450-A | Ligand compound, preparation method thereof and application thereof in asymmetric reaction | 中国科学院福建物质结构研究所 | 2021-10-12 | — | — | CN | disclosed |
| CN-113461721-A | BODIPY near-infrared fluorescent dye with large Stokes shift and preparation method thereof | 南京林业大学 | 2021-10-01 | — | — | CN | disclosed |
| EP-3673908-A1 | ANTI-TUMOR EFFECT POTENTIATOR | Taiho Pharmaceutical Co., Ltd. (JP) | 2020-07-01 | — | — | EP | disclosed |
| CN-109923114-A | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2019-06-21 | — | — | CN | disclosed |
| US-20180194773-A1 | BICYCLIC HETEROCYCLIC AMIDE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-07-12 | — | — | US | disclosed |
| US-9828362-B2 | 1,4-disubstituted imidazole derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-11-28 | — | — | US | disclosed |
| US-20170166552-A1 | 1,4-DISUBSTITUTED IMIDAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2017-06-15 | — | — | US | disclosed |
| EP-2909192-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-17 | — | — | EP | disclosed |
| EP-2900645-A1 | 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION | Bayer CropScience AG (DE) | 2015-08-05 | — | — | EP | disclosed |
| CN-104812790-A | Organopolysiloxane graft polymer | KAO CORP | 2015-07-29 | — | — | CN | disclosed |
| US-8895565-B2 | Heterocyclic compound and use of the same | NISHIO TETSUYA (JP) | 2014-11-25 | — | — | US | disclosed |
| US-20110319618-A1 | HETEROCYCLIC COMPOUND AND USE OF THE SAME | NISHIO TETSUYA (JP) | 2011-12-29 | — | — | US | disclosed |
| EP-0745473-B1 | Oriented film including polystyrene polymer having syndiotactic configuration | TOYO BOSEKI (JP) | 2002-12-11 | — | — | EP | disclosed |
| US-5707719-A | Oriented film including polystyrene polymer having syndiotactic configuration | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0745473-A2 | Oriented film including polystyrene polymer having syndiotactic configuration | Toyo Boseki Kabushiki Kaisha (JP) | 1996-12-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166552-A1 | 1,4-DISUBSTITUTED IMIDAZOLE DERIVATIVE | NR4A3, NR0B1, NR2C2 | TP53 247/4885TDP1 4690/4885GABRA1 1692/4885 |
| US-20110319618-A1 | HETEROCYCLIC COMPOUND AND USE OF THE SAME | CYP2D6, CYP2B6, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | TP53 3457/4885TDP1 4545/4885GABRA1 1156/4885 |
| US-11661397-B2 | 1,4-disubstituted imidazole derivative | NR4A3, NR0B1, NR2C2 | TP53 247/4885TDP1 4690/4885GABRA1 1692/4885 |
| US-20180194773-A1 | BICYCLIC HETEROCYCLIC AMIDE DERIVATIVE | NR0B1, NR2E1, NR0B2 | TP53 396/4885TDP1 4583/4885GABRA1 1311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.