Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7612363 | 0.86 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2NR3C1KMT2A | |
| SCHEMBL7614703 | 0.85 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2PTGDR2NR3C1 | |
| SCHEMBL7611594 | 0.83 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2NR3C1KMT2A | |
| SCHEMBL7614695 | 0.82 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2PTGDR2NR3C1 | |
| SCHEMBL7610293 | 0.81 | RAB9A (0.46) | NPC1RAB9ASMN1; SMN2NR3C1KMT2A | |
| SCHEMBL7607642 | 0.79 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2NR3C1KMT2A | |
| SCHEMBL7605875 | 0.77 | ADRB1 (0.46) | NPC1RAB9ASMN1; SMN2NR3C1ADRB2 | |
| SCHEMBL7608356 | 0.75 | ALOX5 (0.44) | LMNAMMP13MMP2 | |
| SCHEMBL7606266 | 0.74 | ELANE (0.42) | LMNA | |
| SCHEMBL7606841 | 0.74 | NR1H3 (0.41) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230210-A1 | AMINOALCOHOL DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001036375-A1 | AMINOALCOHOL DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-25 | — | — | WO | disclosed |