SCHEMBL761304

SCHEMBL761304

O=c1cc(C(F)(F)F)[nH]n1-c1cccc(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.50
LMNA P02545 3/20 0.50
ALDH1A1 P00352 1/20 0.50
POLB P06746 1/20 0.50
BLM P54132 1/20 0.50
ATM Q13315 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
MAOA P21397 4/20 0.49
MAOB P27338 4/20 0.49
ALKBH5 Q6P6C2 1/20 0.48
NOX4 Q9NPH5 1/20 0.43
KMT2A Q03164 5/20 0.43
MEN1 O00255 4/20 0.43
GAA P10253 3/20 0.43
HTT P42858 3/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
CRHBP P24387 2/20 0.43
CRHR2 Q13324 2/20 0.43
HPGD P15428 2/20 0.43
NOD2 Q9HC29 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11478321 0.84 ALKBH5 (0.66) MAPTLMNAALDH1A1POLBBLM
SCHEMBL11483364 0.84 ALKBH5 (0.54) MAPTLMNAALDH1A1POLBBLM
SCHEMBL486072 0.83 LMNA (0.70) MAPTLMNAALDH1A1POLBBLM
SCHEMBL11491891 0.80 NOX4 (0.47) MAPTLMNAALDH1A1POLBBLM
SCHEMBL11478374 0.79 MAPT (0.48) MAPTLMNAALDH1A1POLBBLM
SCHEMBL4023307 0.76 MAPT (0.57) MAPTLMNAALDH1A1ALKBH5NOX4
SCHEMBL10948802 0.73 MEN1 (0.49) MAPTLMNAALDH1A1NOX4KMT2A
SCHEMBL9808001 0.72 MEN1 (0.56) MAPTLMNAALDH1A1POLBBLM
SCHEMBL11300860 0.72 ALKBH5 (0.72) MAPTALDH1A1ALKBH5KMT2AMEN1
SCHEMBL11633623 0.72 MET (0.41) MAOAMAOBSMN1; SMN2CRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2050745-B1 N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT OTSUKA AGRITECHNO CO LTD (JP) 2012-03-21 EP disclosed
US-7994094-B2 N-pyridylpiperidine compound, method for producing the same, and pest control agent OTSUKA AGRITECHNO CO., LTD. (JP) 2011-08-09 US disclosed
US-20100137582-A1 N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT OTSUKA CHEMICAL CO., LTD. (JP) 2010-06-03 US disclosed
EP-2050745-A1 N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT Otsuka Chemical Co., Ltd. (JP) 2009-04-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137582-A1 N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT HRH4, NOX4, PRDX4 MAPT 3506/4885LMNA 4100/4885ALDH1A1 2550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.