Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | PER2 | O15055 | 3/20 | 0.31 |
| ▸ | CRY1 | Q16526 | 3/20 | 0.31 |
| ▸ | CRY2 | Q49AN0 | 3/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7615052 | 0.93 | KDM4E (0.39) | KDM4EALDH1A1HTTHTR6PTGER4 | |
| SCHEMBL7615359 | 0.89 | DNM1 (0.36) | KDM4EALDH1A1HTR6PTGER4CYP19A1 | |
| Hydrochloric Acid SCHEMBL8472661 | 0.89 | KDM4E (0.42) | KDM4EALDH1A1HTTHTR6PTGER4 | |
| SCHEMBL8474349 | 0.88 | KMT2A (0.37) | KDM4EALDH1A1HTTPTGER4TSHR | |
| SCHEMBL7614890 | 0.88 | KMT2A (0.37) | KDM4EALDH1A1HTTPTGER4TSHR | |
| SCHEMBL7618604 | 0.86 | HTR6 (0.35) | HTR6PTGER4TOP2APER2CRY1 | |
| SCHEMBL8474836 | 0.85 | ENPP1 (0.37) | KDM4EALDH1A1HTTHDAC1TSHR | |
| SCHEMBL8475130 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1HTTHTR6PTGER4 | |
| SCHEMBL7615408 | 0.84 | CNR2 (0.36) | KDM4EALDH1A1HTR6PTGER4CNR2 | |
| SCHEMBL8475477 | 0.83 | KDM4E (0.39) | KDM4EALDH1A1HTTHTR6PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741132-B1 | INDOLE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-5891902-A | OSTEOPOROSIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0741132-A1 | INDOLE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-11-06 | — | — | EP | disclosed |