Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294 | 0.91 | P2RX7 (0.36) | KMT2ASCN9AMEN1P2RX7MAPT | |
| SCHEMBL6153 | 0.89 | GAA (0.36) | P2RX7ALDH1A1MAPTGAA | |
| SCHEMBL2182 | 0.88 | SCN9A (0.38) | KMT2ASCN9AMEN1ATMP2RX7 | |
| SCHEMBL6445 | 0.86 | CHRM1 (0.36) | ALDH1A1MAPTSMN1; SMN2KDM4ETSHR | |
| SCHEMBL7572 | 0.85 | SLC26A6 (0.36) | ALDH1A1TDP1HTTSMN1; SMN2TSHR | |
| SCHEMBL6765 | 0.85 | BRD4 (0.33) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2605 | 0.84 | CYP2C9 (0.41) | SCN9AP2RX7MAPTPOLBSCN5A | |
| SCHEMBL11897090 | 0.82 | HDAC1 (0.36) | KMT2AMEN1ALDH1A1TDP1ALOX15 | |
| SCHEMBL7532 | 0.81 | ALOX5 (0.35) | KMT2AMEN1ALDH1A1TDP1MAPT | |
| SCHEMBL6547 | 0.81 | KMT2A (0.39) | KMT2ASCN9AMEN1ATMP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |