SCHEMBL6445

SCHEMBL6445

CCOC(=O)CC1(c2ccc(-c3ccc(-c4onc(C)c4N(C)CCCc4ccc(Cl)cc4)cc3)cc2)CC1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 2/20 0.36
HTR2A P28223 1/20 0.36
MCHR1 Q99705 1/20 0.36
ALDH1A1 P00352 2/20 0.34
FFAR4 Q5NUL3 1/20 0.34
JAK2 O60674 1/20 0.34
JAK1 P23458 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
KDM4E B2RXH2 1/20 0.34
HPGD P15428 1/20 0.34
TP53 P04637 1/20 0.34
GAA P10253 2/20 0.33
OPRM1 P35372 1/20 0.33
POLB P06746 2/20 0.33
MAPT P10636 1/20 0.33
RAB9A P51151 2/20 0.33
NPC1 O15118 1/20 0.33
LMNA P02545 1/20 0.33
TSHR P16473 1/20 0.33
SLC26A6 Q9BXS9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7532 0.92 ALOX5 (0.35) CHRM1ALDH1A1SMN1; SMN2KDM4EHPGD
SCHEMBL6765 0.91 BRD4 (0.33) ALDH1A1JAK2JAK1SMN1; SMN2KDM4E
SCHEMBL7148 0.91 ALDH1A1 (0.38) CHRM1HTR2AMCHR1ALDH1A1FFAR4
SCHEMBL6153 0.89 GAA (0.36) ALDH1A1FFAR4JAK2JAK1GAA
SCHEMBL1323 0.88 OPRM1 (0.44) CHRM1HTR2AMCHR1ALDH1A1SMN1; SMN2
SCHEMBL6973 0.87 BRD4 (0.36) CHRM1ALDH1A1SMN1; SMN2KDM4EHPGD
SCHEMBL7572 0.86 SLC26A6 (0.36) ALDH1A1SMN1; SMN2GAAPOLBLMNA
SCHEMBL7632 0.86 KMT2A (0.38) ALDH1A1SMN1; SMN2KDM4EGAAPOLB
SCHEMBL6236 0.85 GAA (0.34) GAA
SCHEMBL11897090 0.84 HDAC1 (0.36) ALDH1A1SMN1; SMN2KDM4ETP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed