SCHEMBL7642467

SCHEMBL7642467

CC(C)=CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

nearest known ligand 0.70

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 13/20 0.70
MAPT P10636 2/20 0.57
LMNA P02545 2/20 0.57
MEN1 O00255 1/20 0.57
GSTP1 P09211 1/20 0.57
TTPA P49638 1/20 0.57
KMT2A Q03164 1/20 0.57
USP2 O75604 1/20 0.57
THRB P10828 1/20 0.57
CYP2C9 P11712 1/20 0.57
CYP2C19 P33261 1/20 0.57
NR1I2 O75469 2/20 0.56
CYP4F2 P78329 1/20 0.50
PTGS1 P23219 1/20 0.49
PTGS2 P35354 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23166794 1.00 ALOX5 (0.70) ALOX5MAPTLMNAMEN1GSTP1
SCHEMBL29670818 1.00 ALOX5 (0.70) ALOX5MAPTLMNAMEN1GSTP1
SCHEMBL31369406 1.00 ALOX5 (0.70) ALOX5MAPTLMNAMEN1GSTP1
SCHEMBL23166879 1.00 ALOX5 (0.70) ALOX5MAPTLMNAMEN1GSTP1
SCHEMBL29670814 1.00 ALOX5 (0.70) ALOX5MAPTLMNAMEN1GSTP1
SCHEMBL23166910 0.93 ALOX5 (0.82) ALOX5MAPT
SCHEMBL23167044 0.93 ALOX5 (0.82) ALOX5MAPT
Alpha-Tocotrienol SCHEMBL2364445 0.93 ALOX5 (0.82) ALOX5MAPT
Alpha-Tocotrienol SCHEMBL31053049 0.93 ALOX5 (0.82) ALOX5MAPT
SCHEMBL23166911 0.93 ALOX5 (0.82) ALOX5MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240368098-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2024-11-07 US disclosed
US-20240293339-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA Stealth Bio Therapeutics Inc. (US) 2024-09-05 US disclosed
US-12049455-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia STEALTH BIOTHERAPEUTICS INC. (US) 2024-07-30 US disclosed
EP-4351547-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA Stealth BioTherapeutics Inc. (US) 2024-04-17 EP disclosed
US-20230303506-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2023-09-28 US disclosed
US-11584728-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia STEALTH BIOTHERAPEUTICS INC. (US) 2023-02-21 US disclosed
WO-2022261347-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2022-12-15 WO disclosed
EP-4038076-A1 CHINONE-, HYDROCHINOME- AND NAPHTHOCHINONE-ANALOGUES OF VATIQUIONE FOR TREATMENT OF MITOCHONDRIAL DISORDER DISEASES Stealth BioTherapeutics Inc. (US) 2022-08-10 EP disclosed
CN-114746430-A Quinone-, hydroquinone-and naphthoquinone-analogues of vattinoquinone for the treatment of mitochondrial disorders 康德生物医疗有限公司 2022-07-12 CN disclosed
US-20210206736-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. 2021-07-08 US disclosed
WO-2021067836-A1 CHINONE-, HYDROCHINOME- AND NAPHTHOCHINONE-ANALOGUES OF VATIQUIONE FOR TREATMENT OF MITOCHONDRIAL DISORDER DISEASES STEALTH BIOTHERAPEUTICS CORP (MC) 2021-04-08 WO disclosed
US-8106223-B2 Process for the production of alpha-tocotrienol and derivatives EDISON PHARMACEUTICALS, INC. (US) 2012-01-31 US disclosed
US-20100105930-A1 PROCESS FOR THE PRODUCTION OF ALPHA-TOCOTRIENOL AND DERIVATIVES PTC THERAPEUTICS, INC. 2010-04-29 US disclosed
US-6465548-B1 6-HYDROXYCHROMAN DERIVATIVE WITH PHOSPHORUS AND PHENOLIC ANTIOXIDANTS; HEAT, LIGHT AND OXIDATION STABILITY DURING MOLDING YOSHITOMI FINE CHEMICALS, LTD. (JP) 2002-10-15 US disclosed
EP-0414106-B1 Process for the preparation of terpenes EISAI CO LTD (JP) 1996-03-27 EP disclosed
US-5073659-A Alkylation, Grignard reagent, zinc chloride catalyst and coppe r compound EISAI CO., LTD. (JP) 1991-12-17 US disclosed
US-4634778-A Process for preparing chlorinated ethylenic derivatives RHONE-POULENC SANTE (FR) 1987-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240293339-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA AIFM2, FH, FECH ALOX5 288/4885MAPT 322/4885LMNA 528/4885
US-20230303506-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA FH, COQ8A, TFAM ALOX5 1622/4885MAPT 1057/4885LMNA 1541/4885
US-11584728-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia FH, COQ8A, TFAM ALOX5 1622/4885MAPT 1057/4885LMNA 1541/4885
US-20210206736-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA FH, COQ8A, TFAM ALOX5 1622/4885MAPT 1057/4885LMNA 1541/4885
US-12049455-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia FH, COQ8A, TFAM ALOX5 1622/4885MAPT 1057/4885LMNA 1541/4885
US-20240368098-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA FH, COQ8A, TFAM ALOX5 1622/4885MAPT 1057/4885LMNA 1541/4885
US-20100105930-A1 PROCESS FOR THE PRODUCTION OF ALPHA-TOCOTRIENOL AND DERIVATIVES TTPA, LCAT, PCTP ALOX5 76/4885MAPT 2318/4885LMNA 2953/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.