Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652914 | 0.81 | LMNA (0.46) | HPGDALDH1A1SMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL8343433 | 0.79 | ATM (0.47) | HPGDALDH1A1RAB9ANPC1HTT | |
| SCHEMBL7650664 | 0.78 | ADORA3 (0.44) | HPGDALDH1A1RAB9ANPC1HTT | |
| SCHEMBL7652506 | 0.78 | TNKS (0.50) | HPGDALDH1A1RAB9ANPC1HTT | |
| SCHEMBL3170478 | 0.76 | MAPK1 (0.47) | HPGDALDH1A1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL7652937 | 0.75 | TNKS (0.47) | HPGDALDH1A1RAB9ANPC1HTT | |
| SCHEMBL15871236 | 0.73 | HPGD (0.56) | HPGDALDH1A1HTTSMN1; SMN2HSD17B10 | |
| SCHEMBL7656228 | 0.73 | ALDH1A1 (0.49) | HPGDALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL7660378 | 0.72 | ALDH1A1 (0.53) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7652867 | 0.72 | ALDH1A1 (0.48) | ALDH1A1HTTHSD17B10KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492407-B2 | NEUROPROTECTIVE ACTIVITY | BOEHRINGER IMGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |