Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 6/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650664 | 0.86 | ADORA3 (0.44) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL7660378 | 0.85 | ALDH1A1 (0.53) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL7654423 | 0.85 | ALDH1A1 (0.47) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL7655377 | 0.84 | ADORA3 (0.46) | KMT2AGAAMAPTALDH1A1ADORA2A | |
| SCHEMBL7652832 | 0.84 | RPA1 (0.51) | NPC1RAB9AKMT2AGAAMAPT | |
| SCHEMBL7656767 | 0.84 | GAA (0.54) | GAAKDM4EALDH1A1HTTL3MBTL1 | |
| SCHEMBL7656031 | 0.82 | L3MBTL1 (0.58) | NPC1RAB9AATMKMT2AMEN1 | |
| SCHEMBL15137319 | 0.81 | TYMP (0.43) | KMT2AMEN1GAAMAPTKDM4E | |
| SCHEMBL16590395 | 0.81 | MGLL (0.44) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL7651289 | 0.80 | MAPT (0.44) | KMT2AMEN1GAASCN2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492407-B2 | NEUROPROTECTIVE ACTIVITY | BOEHRINGER IMGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |