Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.38 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.38 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657876 | 0.89 | ALDH1A1 (0.40) | TARBP2 | |
| SCHEMBL7655215 | 0.87 | PTGS2 (0.41) | SMN1; SMN2TARBP2TP53ALOX5 | |
| SCHEMBL7656298 | 0.86 | TDP1 (0.39) | SMN1; SMN2TARBP2TP53ALOX5 | |
| SCHEMBL7660368 | 0.85 | MAPT (0.39) | SMN1; SMN2TARBP2TP53ALOX5 | |
| SCHEMBL6913771 | 0.85 | ALOX5 (0.48) | ALOX5 | |
| SCHEMBL7656347 | 0.84 | ALOX5 (0.39) | SMN1; SMN2TARBP2TP53ALOX5 | |
| SCHEMBL6914615 | 0.73 | TARBP2 (0.46) | TARBP2TP53ALOX5 | |
| SCHEMBL7662370 | 0.72 | ALOX5 (0.65) | TP53ALOX5 | |
| SCHEMBL8080370 | 0.72 | ALOX5 (0.52) | SMN1; SMN2ALOX5 | |
| SCHEMBL7656847 | 0.72 | AURKA (0.46) | ABL1SMN1; SMN2MAOBPPARDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340704-B1 | TREATING NERVE DISEASE OR BONE/JOINT DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-01-22 | — | — | US | disclosed |