SCHEMBL765941

SCHEMBL765941

C=Cc1ccc(F)c(Cl)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.43
TRPA1 O75762 2/20 0.42
MAPT P10636 2/20 0.38
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
HTT P42858 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
TP53 P04637 2/20 0.35
TDP1 Q9NUW8 1/20 0.35
SLC2A1 P11166 1/20 0.35
MAOB P27338 1/20 0.35
LMNA P02545 1/20 0.35
POLB P06746 1/20 0.35
PKM P14618 1/20 0.35
MAPK1 P28482 1/20 0.35
NFE2L2 Q16236 1/20 0.34
ITGB3 P05106 1/20 0.34
ITGAV P06756 1/20 0.34
RAPGEF4 Q8WZA2 1/20 0.34
KAT2B Q92831 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6584379 0.83 TRPA1 (0.41) ALDH1A1TRPA1MAPTKMT2AMEN1
SCHEMBL4902284 0.82 ALDH1A1 (0.43) ALDH1A1TRPA1MAPTTP53TDP1
SCHEMBL73084 0.78 TRPA1 (0.41) ALDH1A1TRPA1MAPTKMT2AMEN1
SCHEMBL73085 0.78 TRPA1 (0.41) ALDH1A1TRPA1MAPTKMT2AMEN1
SCHEMBL248639 0.78 NFE2L2 (0.50) ALDH1A1TRPA1MAPTTP53TDP1
SCHEMBL14890 0.78 ALDH1A1 (0.58) ALDH1A1MAPTKMT2ANPSR1TP53
SCHEMBL30620702 0.78 ALDH1A1 (0.58) ALDH1A1MAPTKMT2ANPSR1TP53
SCHEMBL29662132 0.78 NFE2L2 (0.50) ALDH1A1TRPA1MAPTTP53TDP1
SCHEMBL42757 0.77 ALDH1A1 (0.64) ALDH1A1TRPA1MAPTKMT2AMEN1
SCHEMBL16618736 0.77 TRPA1 (0.46) ALDH1A1TRPA1MAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735431-A2 MK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME GILEAD SCIENCES, INC. (US) 2026-05-06 EP disclosed
WO-2025006568-A2 MK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME GILEAD SCIENCES, INC. (US) 2025-01-02 WO disclosed
EP-4127039-B1 HIGH DARKNESS AND HIGH GLOSS DIMENSIONALLY STABLE THERMOPLASTIC SMMA MOLDING COMPOSITION INEOS STYROLUTION GROUP GMBH (DE) 2024-11-20 EP disclosed
EP-4251696-B1 UV RESISTANT SMMA COPOLYMERS WITH LOW HAZE AND HIGH CLARITY INEOS STYROLUTION GROUP GMBH (DE) 2024-11-20 EP disclosed
US-20240317968-A1 HIGH CLARITY AND LOW HAZE UV STABILIZED STYRENE AND METHYL METHACRYLATE COPOLYMERS INEOS STYROLUTION GROUP GMBH (DE) 2024-09-26 US disclosed
US-20240228488-A1 HETEROARYL INHIBITORS OF PLASMA KALLIKREIN TAKEDA PHARMACEUTICALS CO (JP) 2024-07-11 US disclosed
US-20240228488-A1 HETEROARYL INHIBITORS OF PLASMA KALLIKREIN TAKEDA PHARMACEUTICALS CO (JP) 2024-07-11 US disclosed
CN-118234789-A High clarity, low haze and UV stable styrene-methyl methacrylate copolymers 英力士苯领集团股份公司 2024-06-21 CN disclosed
US-20240010825-A1 UV RESISTANT SMMA COPOLYMERS WITH LOW HAZE AND HIGH CLARITY INEOS STYROLUTION GROUP GMBH (DE) 2024-01-11 US disclosed
WO-2023211997-A1 ANTIVIRAL COMPOUNDS ENANTA PHARMACEUTICALS, INC. (US) 2023-11-02 WO disclosed
US-4038166-A ELECTROCOATING, SYNTHETIC ORGANIC RESINS, AMINE-ALDEHYDE CONDENSATE PPG INDUSTRIES, INC. (US) 1977-07-26 US disclosed
US-4035275-A ELECTRODEPOSITION, CATIONIC EPOXY RESINS PPG INDUSTRIES, INC. (US) 1977-07-12 US disclosed
US-4031290-A ALPHA-BETA MONOMERS, CATALYSIS PPG INDUSTRIES, INC. (US) 1977-06-21 US disclosed
US-4016332-A OF ETHYLENICALLY UNSATURATED MONOMERS PPG INDUSTRIES, INC. (US) 1977-04-05 US disclosed
US-3975346-A ELECTRO-DEPOSITION PPG INDUSTRIES, INC. (US) 1976-08-17 US disclosed
US-3959106-A EPOXY COMPOUNDS; SULFIDES PPG INDUSTRIES, INC. (US) 1976-05-25 US disclosed
US-3939051-A Process for electrodeposition of cationic thermosetting compositions PPG INDUSTRIES, INC. (US) 1976-02-17 US disclosed
US-3937679-A COATINGS, AMMONIUM, SULFONIUM, OR PHOSPHONIUM ACID SALT, AMINE-ALDEHYDE CONDENSATE, AND A METHYOL PHENOL ETHER PPG INDUSTRIES, INC. (US) 1976-02-10 US disclosed
US-3936405-A CATIONIC POLYMER PPG INDUSTRIES, INC. (US) 1976-02-03 US disclosed
US-3933940-A Mercaptan blocked thermosetting copolymers PPG INDUSTRIES, INC. (US) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240228488-A1 HETEROARYL INHIBITORS OF PLASMA KALLIKREIN KLKB1, KLK5, KLK1 ALDH1A1 3026/4885TRPA1 4811/4885MAPT 3787/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.