Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655578 | 0.84 | PNP (0.39) | PNPACHEADRB2CYP1A2CYP2D6 | |
| SCHEMBL7663573 | 0.83 | PNP (0.36) | PNPADRB2CYP1A2CYP2D6 | |
| SCHEMBL7108772 | 0.78 | PNP (0.38) | PNPTYMPPDCD1CD274DNM1 | |
| SCHEMBL10533348 | 0.73 | DNM1 (0.57) | DNM1CYP1A2CYP2D6BCHE | |
| SCHEMBL7103571 | 0.73 | PNP (0.42) | PNPTYMPPDCD1CD274DNM1 | |
| SCHEMBL3079282 | 0.73 | DNM1 (0.57) | DNM1CYP1A2CYP2D6BCHE | |
| SCHEMBL23052827 | 0.73 | ADRB2 (0.46) | ADRB2DNM1BCHE | |
| SCHEMBL7657692 | 0.73 | CD274 (0.46) | PNPACHEPDCD1CD274ADRB2 | |
| SCHEMBL7652647 | 0.72 | GSR (0.46) | PDCD1CD274CYP1A2CYP2D6 | |
| SCHEMBL7663759 | 0.71 | TYMP (0.35) | PNPTYMPPDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |