Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | CA2 | P00918 | 16/20 | 0.52 |
| ▸ | CA1 | P00915 | 15/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL766298 | 1.00 | MAPT (0.61) | MAPTCA2CA1TRPA1NPC1 | |
| SCHEMBL18725593 | 0.95 | CA2 (0.58) | MAPTCA2CA1TRPA1NPC1 | |
| SCHEMBL18725592 | 0.95 | CA2 (0.58) | MAPTCA2CA1TRPA1NPC1 | |
| SCHEMBL28820952 | 0.95 | MAPT (0.56) | MAPTCA2CA1TRPA1NPC1 | |
| SCHEMBL28556565 | 0.87 | TRPA1 (0.67) | MAPTCA2CA1TRPA1NPC1 | |
| Terephthalic Acid SCHEMBL31095057 | 0.84 | CA2 (0.68) | MAPTCA2CA1CA4 | |
| Terephthalic Acid SCHEMBL107909 | 0.84 | CA2 (0.68) | MAPTCA2CA1CA4 | |
| Terephthalic Acid SCHEMBL9930546 | 0.81 | CA2 (0.65) | MAPTCA2CA1CA4 | |
| Terephthalic Acid SCHEMBL7910695 | 0.81 | CA2 (0.65) | MAPTCA2CA1CA4 | |
| Terephthalic Acid SCHEMBL15641843 | 0.81 | CA2 (0.74) | MAPTCA2CA1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10125016-B2 | Nanoporous carbohydrate frameworks and the sequestration and detection of molecules using the same | NORTHWESTERN UNIVERSITY (US) | 2018-11-13 | — | — | US | disclosed |
| US-20150322174-A1 | Nanoporous Carbohydrate Frameworks and the Sequestration and Detection of Molecules Using the Same | THE UNIVERSITY OF ST. ANDREWS (GB) | 2015-11-12 | — | — | US | disclosed |
| US-9085460-B2 | Nanoporous carbohydrate frameworks and the sequestration and detection of molecules using the same | NORTHWESTERN UNIVERSITY (US) | 2015-07-21 | — | — | US | disclosed |
| US-20120070904-A1 | NANOPOROUS CARBOHYDRATE FRAMEWORKS AND THE SEQUESTRATION AND DETECTION OF MOLECULES USING THE SAME | THE UNIVERSITY OF ST. ANDREWS (GB) | 2012-03-22 | — | — | US | disclosed |