Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 3/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.42 |
| ▸ | CDK2 | P24941 | 6/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | GALR1 | P47211 | 4/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666144 | 0.91 | CDK4 (0.45) | PDGFRACCNE1CDK2CTSLMEN1 | |
| SCHEMBL7358873 | 0.87 | CTSL (0.46) | PDGFRACCNE1CDK2ABL1BTK | |
| SCHEMBL7674300 | 0.83 | CTSL (0.50) | PDGFRACCNE1CDK2CTSLCDK1 | |
| SCHEMBL7661515 | 0.82 | CCNE1 (0.54) | PDGFRACCNE1CDK2CTSLCDK1 | |
| SCHEMBL7673595 | 0.82 | KDM4E (0.45) | PDGFRACCNE1CDK2CTSLCDK1 | |
| SCHEMBL7674302 | 0.81 | PDGFRA (0.44) | PDGFRACCNE1CDK2CTSLCDK1 | |
| SCHEMBL7672897 | 0.81 | LMNA (0.50) | PDGFRACCNE1CDK2MEN1LMNA | |
| SCHEMBL7671191 | 0.81 | GBA1 (0.48) | PDGFRACCNE1CDK2CTSLMAPT | |
| SCHEMBL7666120 | 0.79 | PDGFRA (0.49) | PDGFRACCNE1CDK2CTSLLMNA | |
| SCHEMBL7674135 | 0.79 | PDGFRA (0.43) | PDGFRACCNE1CDK2CTSLCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |