Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169096 | 0.89 | ALDH1A1 (0.47) | ALDH1A1SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL7665850 | 0.79 | ALDH1A1 (0.53) | ALDH1A1SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL7671714 | 0.78 | LMNA (0.55) | ALDH1A1SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL7665165 | 0.75 | OPRD1 (0.56) | ALDH1A1SIGMAR1L3MBTL1OPRD1OPRK1 | |
| SCHEMBL6170069 | 0.71 | SIGMAR1 (0.57) | ALDH1A1SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL4233587 | 0.70 | OPRL1 (0.59) | KMT2AKDM4EDRD2DRD4 | |
| SCHEMBL2701086 | 0.70 | SIGMAR1 (0.61) | ALDH1A1SIGMAR1L3MBTL1KDM4EOPRK1 | |
| SCHEMBL4816046 | 0.69 | ALDH1A1 (0.80) | ALDH1A1SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL6171225 | 0.69 | SIGMAR1 (0.54) | ALDH1A1SIGMAR1L3MBTL1OPRD1OPRK1 | |
| SCHEMBL7820476 | 0.69 | L3MBTL1 (0.54) | ALDH1A1SIGMAR1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444679-B1 | NEUROLOGICAL AND GASTROINTESTINAL DISORDERS; DELTA OPIOID LIGANDS OR OPIOID RECEPTORS | PFIZER INC | 2002-09-03 | — | — | US | disclosed |
| EP-1038872-A1 | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands | Pfizer Products Inc. (US) | 2000-09-27 | — | — | EP | disclosed |