SCHEMBL7670805

SCHEMBL7670805

COc1ccc(CC(C)(NC(=O)O)C(=O)NC(CO)C(O)c2ccccc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 1/20 0.44
TACR3 P29371 1/20 0.44
KDM4E B2RXH2 1/20 0.43
GAA P10253 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
GPR88 Q9GZN0 1/20 0.42
MMP1 P03956 3/20 0.41
MMP13 P45452 3/20 0.41
ATM Q13315 1/20 0.41
ALDH1A1 P00352 1/20 0.40
KMT2A Q03164 1/20 0.40
NPY5R Q15761 1/20 0.40
MMP9 P14780 2/20 0.40
CASR P41180 2/20 0.40
CNR2 P34972 1/20 0.40
ROCK2 O75116 1/20 0.39
ROCK1 Q13464 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7670973 0.89 NPY5R (0.46) TACR3KDM4EKMT2ANPY5R
SCHEMBL7665676 0.88 TACR3 (0.43) TACR1TACR3NPY5RMMP9
SCHEMBL9698341 0.79 CCKBR (0.39) TACR1TACR3
SCHEMBL3112591 0.75 GPR88 (0.49) KDM4EGAASMN1; SMN2TDP1GPR88
SCHEMBL3112603 0.75 GPR88 (0.49) KDM4EGAASMN1; SMN2TDP1GPR88
SCHEMBL9539141 0.75 ITGB3 (0.46) TACR1TACR3SMN1; SMN2GPR88NPY5R
SCHEMBL8892928 0.75 TACR1 (0.57) TACR1TACR3
SCHEMBL9539374 0.73 TACR3 (0.45) TACR1TACR3KDM4EKMT2ANPY5R
SCHEMBL9699646 0.72 TACR1 (0.43) TACR1TACR3
SCHEMBL12406505 0.71 ATM (0.60) GPR88ATMALDH1A1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993003721-A1 CHOLECYSTOKININ ANTAGONISTS USEFUL FOR TREATING DEPRESSION WARNER-LAMBERT COMPANY (US) 1993-03-04 WO claimed
WO-1992004025-A1 AMINO ACID ANALOGS AS CCK ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1992-03-19 WO claimed
US-6492531-B1 THE INVENTION CONCERNS CHOLECYSTOKININ (CCK) ANTAGONISTS USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS. ESPECIALLY USEFUL ARE CCK.SUB.B ANTAGONISTS SUCH AS CI-988. WARNER-LAMBERT COMPANY 2002-12-10 US disclosed
US-5217957-A CHOLECYSTOKININ ANTAGONISTS USEFUL FOR TREATING DEPRESSION WARNER-LAMBERT COMPANY (US) 1993-06-08 US disclosed
WO-1992004025-A1 AMINO ACID ANALOGS AS CCK ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1992-03-19 WO disclosed