Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 13/20 | 0.53 |
| ▸ | TMPRSS6 | Q8IU80 | 8/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.48 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.48 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670445 | 0.87 | TMPRSS6 (0.51) | F2TMPRSS6PRSS1TMPRSS15 | |
| SCHEMBL7670690 | 0.87 | TMPRSS6 (0.51) | F2TMPRSS6PRSS1TMPRSS15 | |
| SCHEMBL7671933 | 0.86 | F2 (0.56) | F2TMPRSS6 | |
| SCHEMBL7674174 | 0.78 | MMP1 (0.61) | MEP1B | |
| SCHEMBL7670310 | 0.76 | TMPRSS15 (0.52) | F2TMPRSS6PRSS1TMPRSS15MEP1B | |
| SCHEMBL7669205 | 0.76 | TMPRSS15 (0.52) | F2TMPRSS6PRSS1TMPRSS15MEP1B | |
| SCHEMBL7667468 | 0.76 | MMP1 (0.61) | TMPRSS15MEP1B | |
| SCHEMBL7744358 | 0.73 | PARP10 (0.74) | F2PRSS1TMPRSS15 | |
| SCHEMBL29955316 | 0.73 | ALDH1A1 (0.60) | MEP1B | |
| SCHEMBL7665205 | 0.72 | F2 (0.58) | F2TMPRSS6PRSS1TMPRSS15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |