Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.41 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421842 | 0.90 | L3MBTL1 (0.46) | L3MBTL1NPSR1KDM4EMAPTPOLB | |
| SCHEMBL7701291 | 0.89 | GFER (0.41) | L3MBTL1CASP1KDM4EADAMTS4MMP1 | |
| SCHEMBL7701336 | 0.86 | CASP1 (0.49) | L3MBTL1NPSR1CASP1KDM4EADAMTS4 | |
| SCHEMBL7428250 | 0.85 | KCNA5 (0.44) | CASP1MMP1MMP2MMP13MMP14 | |
| SCHEMBL7659831 | 0.83 | KDM4E (0.48) | L3MBTL1NPSR1KDM4EMAPTPOLB | |
| SCHEMBL7564537 | 0.83 | CA2 (0.54) | NPSR1CASP1MMP1LMNARAB9A | |
| SCHEMBL7666903 | 0.82 | KDM4E (0.47) | L3MBTL1NPSR1KDM4EMAPTPOLB | |
| SCHEMBL7695233 | 0.80 | CAPN1 (0.54) | CASP1MMP1MMP2MMP13MMP14 | |
| SCHEMBL7422050 | 0.79 | KCNA5 (0.49) | KDM4EMMP1MMP13HSD17B10MEN1 | |
| SCHEMBL7606033 | 0.78 | CASP1 (0.37) | CASP1ADAMTS4MMP1MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |