Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7675029 | 0.89 | L3MBTL1 (0.44) | MAPTRAB9ALMNAKMT2AALDH1A1 | |
| SCHEMBL7421842 | 0.80 | L3MBTL1 (0.46) | MAPTRAB9AGAALMNAKMT2A | |
| SCHEMBL7599622 | 0.78 | CAPN1 (0.33) | GFERMAPTSMN1; SMN2GAALMNA | |
| SCHEMBL7428250 | 0.77 | KCNA5 (0.44) | GAAKMT2AMEN1CASP1MMP1 | |
| SCHEMBL7701336 | 0.76 | CASP1 (0.49) | MAPTGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL7564537 | 0.75 | CA2 (0.54) | NPC1RAB9AGAALMNAALDH1A1 | |
| SCHEMBL7659831 | 0.74 | KDM4E (0.48) | MAPTRAB9AGAALMNAKMT2A | |
| SCHEMBL7690197 | 0.73 | CAPN1 (0.51) | SMN1; SMN2LMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL7666903 | 0.73 | KDM4E (0.47) | MAPTSMN1; SMN2RAB9AGAALMNA | |
| SCHEMBL7695233 | 0.73 | CAPN1 (0.54) | CASP1MMP1MMP2MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |