SCHEMBL7687312

SCHEMBL7687312

O=S(=O)(CC(F)(F)C(F)F)c1cc[c]cc1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.33
TP53 P04637 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
PNMT P11086 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7682009 0.81 PNMT (0.37) ALDH1A1MEN1KMT2APNMT
SCHEMBL10872242 0.79 CA2 (0.46) ALDH1A1TP53SMN1; SMN2MEN1KMT2A
SCHEMBL7684910 0.78 MEN1 (0.34) ALDH1A1MEN1KMT2A
SCHEMBL3198080 0.73 ALDH1A1 (0.44) ALDH1A1TP53MEN1KMT2ACA1
SCHEMBL27851864 0.70 CTSK (0.37)
SCHEMBL3203643 0.69 MMP13 (0.39) ALDH1A1TP53MEN1KMT2A
SCHEMBL159760 0.68 PSIP1 (0.58) ALDH1A1TP53MEN1KMT2ACA2
SCHEMBL17134162 0.67 POLB (0.32)
SCHEMBL3202878 0.67 MMP13 (0.44) ALDH1A1TP53MEN1KMT2ACA2
SCHEMBL19239760 0.67 PSIP1 (0.52) ALDH1A1TP53SMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6362206-B1 FUNGICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-26 US disclosed
US-6034248-A FUNGICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-03-07 US disclosed
EP-0884311-A2 Triazole Derivatives and their production Takeda Chemical Industries, Ltd. (JP) 1998-12-16 EP disclosed
US-5792780-A FUNGICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-08-11 US disclosed
EP-0657449-B1 Azole compounds, their production and use as antifungal agents TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-04-08 EP disclosed
EP-0809640-A1 AZOLE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-12-03 EP disclosed
WO-1996025410-A1 AZOLE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-08-22 WO disclosed
US-5545652-A Triazole and imidazole compounds and their use as antifungal therapeutic agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-08-13 US disclosed
EP-0657449-A1 Azole compounds, their production and use as antifungal agents Takeda Chemical Industries, Ltd. (JP) 1995-06-14 EP disclosed