Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694696 | 0.89 | KDM4E (0.47) | L3MBTL1ALDH1A1HPGDGAAHTT | |
| SCHEMBL7666903 | 0.85 | KDM4E (0.47) | L3MBTL1ALDH1A1HPGDGAAHTT | |
| SCHEMBL7701622 | 0.83 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1HPGDGAAHTT | |
| SCHEMBL7701336 | 0.82 | CASP1 (0.49) | L3MBTL1ALDH1A1HPGDGAAHTT | |
| SCHEMBL7689953 | 0.81 | CHRNB2 (0.52) | ACEL3MBTL1HTTCTSLCTSS | |
| SCHEMBL7382832 | 0.77 | ROCK2 (0.51) | L3MBTL1ALDH1A1HPGDGAAHTT | |
| SCHEMBL7787791 | 0.77 | ROCK2 (0.51) | L3MBTL1ALDH1A1HPGDGAAHTT | |
| SCHEMBL7690558 | 0.77 | CAPN1 (0.60) | ACECTSLCTSSCTSKACE2 | |
| SCHEMBL7693478 | 0.76 | ACE (0.45) | ACECTSLCTSSCTSK | |
| SCHEMBL7659831 | 0.75 | KDM4E (0.48) | L3MBTL1ALDH1A1HPGDGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |