Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ICMT | O60725 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694147 | 0.89 | ACE (0.46) | KDM4EL3MBTL1ALDH1A1HPGDGAA | |
| SCHEMBL7659831 | 0.86 | KDM4E (0.48) | KDM4EL3MBTL1ALDH1A1HPGDGAA | |
| SCHEMBL7701622 | 0.85 | L3MBTL1 (0.44) | KDM4EL3MBTL1ALDH1A1HPGDGAA | |
| SCHEMBL7701336 | 0.82 | CASP1 (0.49) | KDM4EL3MBTL1ALDH1A1HPGDGAA | |
| SCHEMBL7698402 | 0.81 | CHRNB2 (0.52) | L3MBTL1HTTKMT2AITGB1ITGA4 | |
| SCHEMBL7690823 | 0.77 | CAPN1 (0.60) | KMT2ACTSSCTSK | |
| SCHEMBL7666903 | 0.76 | KDM4E (0.47) | KDM4EL3MBTL1ALDH1A1HPGDGAA | |
| SCHEMBL7696161 | 0.75 | CTSB (0.43) | L3MBTL1CTSSCTSK | |
| SCHEMBL7787791 | 0.75 | ROCK2 (0.51) | KDM4EL3MBTL1ALDH1A1HPGDGAA | |
| SCHEMBL7382832 | 0.75 | ROCK2 (0.51) | KDM4EL3MBTL1ALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |