Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ICMT | O60725 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701336 | 0.88 | CASP1 (0.49) | L3MBTL1NPSR1MEN1KMT2ARECQL | |
| SCHEMBL7421842 | 0.86 | L3MBTL1 (0.46) | L3MBTL1NPSR1MEN1KMT2ARECQL | |
| SCHEMBL7694696 | 0.85 | KDM4E (0.47) | L3MBTL1NPSR1MEN1KMT2ARECQL | |
| SCHEMBL7694147 | 0.83 | ACE (0.46) | L3MBTL1NPSR1MEN1KMT2ARECQL | |
| SCHEMBL7695358 | 0.82 | CHRNB2 (0.47) | L3MBTL1CA2ITGB1ITGA4ITGB7 | |
| SCHEMBL7691777 | 0.78 | CAPN1 (0.58) | L3MBTL1KMT2ACA2ITGB1ITGA4 | |
| SCHEMBL7675029 | 0.76 | L3MBTL1 (0.44) | L3MBTL1NPSR1MEN1KMT2AKDM4E | |
| SCHEMBL7694857 | 0.76 | CA2 (0.43) | CA1CA2 | |
| SCHEMBL7688546 | 0.75 | KCNA5 (0.46) | BCL2L1 | |
| SCHEMBL7690013 | 0.75 | CAPN1 (0.68) | KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |