Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 9/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7691835 | 0.69 | ALDH1A1 (0.54) | GAALMNAALDH1A1ADORA2BMAPT | |
| SCHEMBL7696536 | 0.67 | LMNA (0.52) | GAALMNAALDH1A1ADORA2BDHFR | |
| SCHEMBL14537801 | 0.64 | ALDH1A1 (0.57) | GAALMNAALDH1A1ADORA2BMAPT | |
| SCHEMBL830786 | 0.59 | FFAR3 (0.40) | GAACYP2C9CYP2C19HTT | |
| SCHEMBL10830282 | 0.59 | ADORA3 (0.45) | GAALMNAALDH1A1MAPTCYP2C9 | |
| SCHEMBL5359112 | 0.59 | GAA (0.59) | GAALMNAALDH1A1MAPTKDM4E | |
| SCHEMBL14513188 | 0.58 | ALDH1A1 (0.50) | GAALMNAALDH1A1ADORA2BPTPN1 | |
| SCHEMBL6732466 | 0.56 | ALDH1A1 (0.46) | GAALMNAALDH1A1KDM4E | |
| SCHEMBL11292115 | 0.55 | TSHR (0.74) | GAALMNAALDH1A1MAPTKDM4E | |
| SCHEMBL11981426 | 0.55 | GAA (0.69) | GAALMNAALDH1A1ADORA2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | claimed |
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | disclosed |