Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | STAT3 | P40763 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7221029 | 0.88 | CHRNB2 (0.36) | CHRNB2CHRNA4CHRNA3CHRNB4CYP11B1 | |
| SCHEMBL7696516 | 0.82 | OPRK1 (0.43) | CHRNB2JAK2CHRNA3CHRNB4OPRL1 | |
| SCHEMBL7699063 | 0.82 | CHRNB2 (0.34) | CHRNB2CHRNA4CHRNA3CHRNB4CYP11B1 | |
| SCHEMBL7221392 | 0.81 | OPRL1 (0.37) | JAK2ABL1KDRSTAT3GSK3B | |
| SCHEMBL7697700 | 0.80 | GRM5 (0.41) | CHRNB2CHRNA4JAK2JAK1TYK2 | |
| SCHEMBL7698935 | 0.78 | CHRNB2 (0.37) | CHRNB2CHRNA4CHRNA3CHRNB4CYP11B1 | |
| SCHEMBL7227978 | 0.75 | CHRNB2 (0.34) | CHRNB2CHRNA4CHRNA3CHRNB4CYP11B1 | |
| SCHEMBL7230387 | 0.75 | KMT2A (0.40) | CHRNB2CHRNA4CHRNA3CHRNB4CYP11B1 | |
| SCHEMBL7223489 | 0.71 | OPRM1 (0.35) | OPRL1 | |
| SCHEMBL7230622 | 0.71 | ALDH1A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002057263-A1 | 8-AZABICYCLO \"3.2.1.! OCTANES AS INSECTICIDES | SYNGENTA LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |