Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182272 | 0.77 | CALM1 (0.44) | MEN1KMT2ATDP1 | |
| SCHEMBL1715426 | 0.77 | HRAS (0.44) | MEN1KMT2AMAOATP53GAA | |
| SCHEMBL218277 | 0.76 | MAOA (0.39) | TDP1MAOA | |
| SCHEMBL1654 | 0.73 | MEN1 (0.78) | MEN1KMT2ATDP1PKMMAOA | |
| Benzene SCHEMBL11697595 | 0.73 | MEN1 (0.78) | MEN1KMT2ATDP1PKMMAOA | |
| SCHEMBL5799878 | 0.73 | MEN1 (0.78) | MEN1KMT2ATDP1PKMMAOA | |
| SCHEMBL333955 | 0.73 | HSD17B10 (0.39) | MEN1KMT2ATDP1PKMMAOA | |
| SCHEMBL9957790 | 0.71 | HTR5A (0.47) | MEN1KMT2ACHRM2GAAMAPT | |
| Hydrochloric Acid SCHEMBL1862144 | 0.71 | MEN1 (0.74) | MEN1KMT2ATDP1PKMMAOA | |
| SCHEMBL21550054 | 0.71 | MEN1 (0.74) | MEN1KMT2ATDP1PKMMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083624-B1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | MERCK PATENT GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| US-9688684-B2 | Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors | MERCK PATENT GMBH (DE) | 2017-06-27 | — | — | US | disclosed |
| US-20160311830-A1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | MERCK PATENT GMBH (DE) | 2016-10-27 | — | — | US | disclosed |
| EP-3083624-A1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | Merck Patent GmbH (DE) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015090507-A1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | MERCK PATENT GMBH (DE) | 2015-06-25 | — | — | WO | disclosed |
| WO-2002064558-A2 | OXAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS CYTOKINE INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311830-A1 | TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS | RORC, RORA, RORB | MEN1 3472/4885KMT2A 3035/4885TDP1 4676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.