Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8668544 | 0.90 | MAOB (0.49) | ALDH1A1MAOBGABRG2GABRB3GABRA5 | |
| SCHEMBL4270551 | 0.88 | NUDT1 (0.51) | ALDH1A1NUDT1MAOBGABRG2GABRB3 | |
| SCHEMBL1564355 | 0.80 | ALDH1A1 (0.64) | ALDH1A1NUDT1HRH4HTTLMNA | |
| SCHEMBL8384805 | 0.80 | PIN1 (0.47) | ALDH1A1NUDT1ALOX5PTGESHRH4 | |
| SCHEMBL8871300 | 0.79 | ALDH1A1 (0.59) | ALDH1A1NUDT1MAOBALOX5HTT | |
| SCHEMBL8561075 | 0.78 | ALOX5 (0.48) | ALDH1A1NUDT1MAOBGABRG2GABRB3 | |
| SCHEMBL11009131 | 0.78 | TSHR (0.52) | MAOBALOX5HTTLMNACYP3A4 | |
| SCHEMBL8565553 | 0.77 | MRGPRX4 (0.45) | ALDH1A1MAOBL3MBTL1GAA | |
| SCHEMBL8669447 | 0.77 | L3MBTL1 (0.45) | ALDH1A1MAOBL3MBTL1GAA | |
| SCHEMBL17995530 | 0.76 | NUDT1 (0.46) | ALDH1A1NUDT1ALOX5PTGESHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37623-E1 | PHENYLTHIO AND PHENYLSELENO PYRIMIDINE ANALOGS | el Kouni, Mahmoud H. | 2002-04-02 | — | — | US | disclosed |
| EP-0725641-B1 | NOVEL INHIBITORS OF URIDINE PHOSPHORYLASE (UrdPase) AND DIHYDROURACIL DEHYDROGENASE (DHUDase) | EL KOUNI MAHMOUD H (US) | 2000-12-13 | — | — | EP | disclosed |
| US-5721241-A | PYRIMIDINE COMPOUND USEFUL TO DISRUPT VIRAL, CANCER, FUNGAL, PARASITE OR BACTERIAL REPLICATION AND DIHYDROURACIL DEHYDROGENASE OR URIDINE PHOSPHORYLASE INHIBITORS | el Kouni, Mahmoud H. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0725641-A4 | — | — | 1996-09-04 | — | — | EP | disclosed |
| EP-0725641-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | El Kouni, Mahmoud H. (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5476855-A | Pyrimidine analogs and nucleosides | el Kouni, Mahmoud H. (US) | 1995-12-19 | — | — | US | disclosed |
| WO-1995012400-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | UAB RESEARCH FOUNDATION (US) | 1995-05-11 | — | — | WO | disclosed |