SCHEMBL7708311

SCHEMBL7708311

c1ccc(Sc2ccc3cc4ccccc4cc3c2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.48
MAOB P27338 3/20 0.48
LMNA P02545 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
ALDH1A1 P00352 2/20 0.44
HSD17B10 Q99714 2/20 0.44
CYP3A4 P08684 1/20 0.44
ALOX15 P16050 1/20 0.44
CASP1 P29466 1/20 0.44
CASP7 P55210 1/20 0.44
HBB P68871 1/20 0.44
HIF1A Q16665 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
MCL1 Q07820 2/20 0.43
MAP2K2 P36507 2/20 0.43
MAP2K1 Q02750 2/20 0.43
BCL2 P10415 1/20 0.43
HAO1 Q9UJM8 1/20 0.43
HTR2C P28335 2/20 0.42
HTR6 P50406 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3281214 0.93 LMNA (0.52) MAOAMAOBLMNASMN1; SMN2ALDH1A1
SCHEMBL11300299 0.93 ALDH1A1 (0.50) MAOAMAOBLMNASMN1; SMN2ALDH1A1
SCHEMBL761802 0.85 LMNA (0.57) LMNASMN1; SMN2ALDH1A1HSD17B10CYP3A4
SCHEMBL30832956 0.85 LMNA (0.57) LMNASMN1; SMN2ALDH1A1HSD17B10CYP3A4
SCHEMBL4319742 0.82 MAOA (0.36) MAOAMAOBLMNASMN1; SMN2ALDH1A1
SCHEMBL8514752 0.82 LMNA (0.47) MAOAMAOBLMNASMN1; SMN2ALDH1A1
SCHEMBL9736553 0.81 ADORA2A (0.41) MAOAMAOBSMN1; SMN2ALDH1A1HSD17B10
SCHEMBL3903397 0.79 MAOA (0.56) MAOAMAOBSMN1; SMN2ALDH1A1HSD17B10
SCHEMBL3904216 0.79 MAOA (0.56) MAOAMAOBSMN1; SMN2ALDH1A1HSD17B10
SCHEMBL3889262 0.79 MAOA (0.56) MAOAMAOBSMN1; SMN2ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5731364-A PHOTORESIST SHIPLEY COMPANY, L.L.C. (US) 1998-03-24 US claimed
US-6358665-B1 ONIUM SALT PRECURSOR FOR GENERATING FLUOROALKYLSULFONATE CLARIANT INTERNATIONAL LTD. (CH) 2002-03-19 US disclosed
EP-1033624-A1 RADIATION-SENSITIVE COMPOSITION OF CHEMICAL AMPLIFICATION TYPE Clariant International Ltd. (CH) 2000-09-06 EP disclosed
US-5731364-A PHOTORESIST SHIPLEY COMPANY, L.L.C. (US) 1998-03-24 US disclosed