Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705606 | 0.90 | CSNK1D (0.55) | CSNK1DMAPTTP53 | |
| SCHEMBL7703034 | 0.83 | CSNK1D (0.53) | CSNK1DAPPADORA1MAPTADORA2A | |
| SCHEMBL7708909 | 0.76 | ADORA2A (0.52) | PDE5ACSNK1DHIF1AADORA2A | |
| SCHEMBL7711803 | 0.76 | F2 (0.47) | CSNK1DADORA3ADORA1MAPTHDAC1 | |
| SCHEMBL7705858 | 0.75 | MAPT (0.46) | PDE5ACSNK1DKCNN3MAPTTP53 | |
| SCHEMBL7708996 | 0.72 | ADORA3 (0.51) | CSNK1DADORA3ADORA1HIF1AMAPT | |
| SCHEMBL7423524 | 0.70 | ALDH1A1 (0.53) | CSNK1DADORA3ADORA1MAPTTP53 | |
| SCHEMBL6873157 | 0.70 | HPGDS (0.51) | CSNK1DPDE2AADORA2ALMNA | |
| SCHEMBL1196472 | 0.69 | MAOB (0.56) | PDE5AAPPHIF1AMAPTHDAC6 | |
| SCHEMBL7709009 | 0.69 | NPC1 (0.44) | ADORA3ADORA1KCNN3MAPTADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |