SCHEMBL7709916

SCHEMBL7709916

O=C(NCCSc1ccc(Cl)cc1)C1CCOCC1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TEAD1 P28347 1/20 0.56
YAP1 P46937 1/20 0.56
TEAD4 Q15561 1/20 0.56
TEAD2 Q15562 1/20 0.56
MAPT P10636 3/20 0.54
POLB P06746 1/20 0.50
KMT2A Q03164 4/20 0.46
MEN1 O00255 3/20 0.46
KDM4E B2RXH2 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HDAC1 Q13547 1/20 0.45
HDAC2 Q92769 1/20 0.45
HPGD P15428 2/20 0.45
FKBP1A P62942 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
LMNA P02545 1/20 0.44
GAA P10253 1/20 0.44
HTT P42858 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7709707 0.82 TEAD1 (0.53) TEAD1YAP1TEAD4TEAD2MAPT
SCHEMBL660740 0.72 TEAD1 (0.71) TEAD1YAP1TEAD4TEAD2MAPT
SCHEMBL1009060 0.70 GFER (0.44) TEAD1YAP1TEAD4TEAD2MAPT
SCHEMBL14241835 0.70 TEAD1 (0.77) TEAD1YAP1TEAD4TEAD2MAPT
SCHEMBL19462367 0.69 ERCC1 (0.57) POLBKMT2AMEN1KDM4EALDH1A1
SCHEMBL15569587 0.69 ALDH1A1 (0.49) MAPTKMT2AMEN1ALDH1A1HDAC1
SCHEMBL23747821 0.68 RAB9A (0.59) POLBKMT2AMEN1ALDH1A1HPGD
SCHEMBL8425539 0.68 FKBP1A (0.42) MAPTPOLBKMT2AMEN1KDM4E
SCHEMBL3349120 0.68 ALDH1A1 (0.67) MAPTPOLBKMT2AMEN1KDM4E
SCHEMBL30475562 0.68 POLB (0.69) MAPTPOLBKMT2AMEN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593102-B1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME (US) 2017-06-07 EP disclosed
EP-2593102-B1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME (US) 2017-06-07 EP disclosed
EP-2555772-B1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME (US) 2017-01-11 EP disclosed
EP-2555772-B1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME (US) 2017-01-11 EP disclosed
US-9193697-B2 Oxazole derivatives useful as modulators of FAAH MERCK SHARP & DOHME CORP. (US) 2015-11-24 US disclosed
US-9193697-B2 Oxazole derivatives useful as modulators of FAAH MERCK SHARP & DOHME CORP. (US) 2015-11-24 US disclosed
US-9193697-B2 Oxazole derivatives useful as modulators of FAAH MERCK SHARP & DOHME CORP. (US) 2015-11-24 US disclosed
US-9073879-B2 Oxazole derivatives useful as modulators of FAAH MERCK SHARP & DOHME CORP. (US) 2015-07-07 US disclosed
US-9073879-B2 Oxazole derivatives useful as modulators of FAAH MERCK SHARP & DOHME CORP. (US) 2015-07-07 US disclosed
US-9073879-B2 Oxazole derivatives useful as modulators of FAAH MERCK SHARP & DOHME CORP. (US) 2015-07-07 US disclosed
US-20130018048-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2013-01-17 US disclosed
US-20130018048-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2013-01-17 US disclosed
US-20130018048-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2013-01-17 US disclosed
US-20130012526-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2013-01-10 US disclosed
US-20130012526-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2013-01-10 US disclosed
US-20130012526-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2013-01-10 US disclosed
WO-2011133447-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2011-10-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130018048-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH FAAH, FAAH2, ALOX5 TEAD1 4333/4885YAP1 3998/4885TEAD4 4289/4885
US-20130012526-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH FAAH, FAAH2, ALOX5 TEAD1 4333/4885YAP1 3998/4885TEAD4 4289/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.