Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206921 | 0.84 | PLA2G7 (0.49) | PNPPLA2G7AOC3 | |
| SCHEMBL5202767 | 0.84 | PDE3B (0.47) | PNPPLA2G7AOC3 | |
| SCHEMBL11542383 | 0.80 | AOC3 (0.60) | PNPPLA2G7AOC3 | |
| SCHEMBL7716578 | 0.80 | PLA2G7 (0.48) | PNPSMN1; SMN2PLA2G7 | |
| SCHEMBL7714354 | 0.75 | PNP (0.51) | PNPPLA2G7NPC1RAB9A | |
| SCHEMBL7714583 | 0.72 | PLA2G7 (0.61) | PNPPLA2G7 | |
| SCHEMBL13039021 | 0.72 | NOS1 (0.42) | AOC3 | |
| SCHEMBL8380918 | 0.72 | LMNA (0.66) | — | |
| SCHEMBL7714536 | 0.71 | NPBWR1 (0.41) | PNP | |
| SCHEMBL7716580 | 0.71 | DAO (0.50) | PLA2G7AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |