Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26418374 | 0.88 | DRD2 (0.51) | DRD2DRD3ALDH1A1SIGMAR1HTR3E | |
| SCHEMBL24124019 | 0.86 | DRD2 (0.50) | DRD2DRD3ALDH1A1SIGMAR1HTR3E | |
| SCHEMBL7715920 | 0.82 | ADRB1 (0.45) | DRD2DRD3ALDH1A1ADRB1LMNA | |
| SCHEMBL7714964 | 0.81 | ADRA1A (0.44) | DRD2ALDH1A1CYP2C19KDM4EADRA1D | |
| SCHEMBL7718924 | 0.81 | TSHR (0.51) | DRD2DRD3 | |
| SCHEMBL8693688 | 0.80 | DRD2 (0.58) | DRD2DRD3ALDH1A1SIGMAR1HTR3E | |
| SCHEMBL7714769 | 0.80 | OPRK1 (0.45) | DRD2DRD3ALDH1A1LMNAMAPT | |
| SCHEMBL7677643 | 0.79 | DRD2 (0.57) | DRD2DRD3ALDH1A1SIGMAR1HTR3E | |
| SCHEMBL7716782 | 0.78 | DRD2 (0.69) | DRD2DRD3ADRA1A | |
| SCHEMBL7714987 | 0.77 | KDM4E (0.44) | DRD2DRD3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376503-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC | 2002-04-23 | — | — | US | disclosed |