Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 9/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.38 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714962 | 0.83 | ADRA1A (0.47) | ADRA1AADRA1BADRA1DDRD2CYP3A4 | |
| SCHEMBL7714901 | 0.81 | DRD2 (0.50) | ADRA1AADRA1BADRA1DDRD2CYP2C19 | |
| SCHEMBL7718945 | 0.81 | DRD2 (0.53) | ADRA1AADRA1BADRA1DDRD2SSTR4 | |
| SCHEMBL6771682 | 0.74 | ADRA1A (0.60) | ADRA1AADRA1BADRA1DDRD2CYP3A4 | |
| SCHEMBL7715920 | 0.74 | ADRB1 (0.45) | ADRA1ADRD2ALDH1A1KDM4E | |
| SCHEMBL24712880 | 0.72 | DRD2 (0.59) | ADRA1AADRA1BADRA1DDRD2CYP3A4 | |
| SCHEMBL5473619 | 0.72 | SLC6A2 (0.62) | ADRA1AADRA1BADRA1DDRD2CYP3A4 | |
| SCHEMBL7714987 | 0.72 | KDM4E (0.44) | DRD2CYP3A4ALDH1A1KDM4E | |
| SCHEMBL7719064 | 0.71 | ADRA1A (0.51) | ADRA1AADRA1BADRA1DDRD2CYP3A4 | |
| Hydrochloric Acid SCHEMBL5858161 | 0.71 | HTR1A (0.61) | ADRA1AADRA1BADRA1DDRD2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376503-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC | 2002-04-23 | — | — | US | disclosed |