Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 11/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263724 | 1.00 | ACHE (0.48) | ACHEKDM1AMAOAMAOBCYP19A1 | |
| SCHEMBL7259713 | 0.85 | HCRTR1 (0.39) | ACHEKDM1AMAOAMAOBCYP19A1 | |
| SCHEMBL7715113 | 0.85 | HCRTR1 (0.39) | ACHEKDM1AMAOAMAOBCYP19A1 | |
| SCHEMBL7717533 | 0.81 | MTNR1B (0.35) | ACHE | |
| SCHEMBL7717534 | 0.81 | MTNR1B (0.35) | ACHE | |
| SCHEMBL8620705 | 0.81 | MTNR1A (0.34) | ACHEKDM1AMAOAMAOB | |
| SCHEMBL8617783 | 0.78 | MTNR1A (0.39) | ACHEKDM1AMAOAMAOB | |
| SCHEMBL8636781 | 0.77 | MAPK1 (0.36) | ACHEKDM1AMAOAMAOB | |
| SCHEMBL178121 | 0.76 | PPARA (0.38) | CYP19A1 | |
| SCHEMBL8647745 | 0.74 | MAPK1 (0.39) | ACHEKDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |