Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993885 | 0.79 | TSHR (0.31) | SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL6130815 | 0.79 | ALOX15 (0.39) | ALOX15SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL30153590 | 0.78 | ARG1 (0.40) | SMN1; SMN2MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL263015 | 0.78 | ALOX15 (0.40) | ALOX15SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL27751170 | 0.78 | ALOX15 (0.40) | ALOX15SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL10663925 | 0.77 | ODC1 (0.53) | ALOX15SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL27464347 | 0.76 | SMN1; SMN2 (0.46) | ALOX15SMN1; SMN2MEN1KMT2ACYP1A2 | |
| Synthalin SCHEMBL29526432 | 0.76 | MEN1 (0.52) | ALOX15SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL6431682 | 0.75 | ARG1 (0.47) | ALOX15SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL202490 | 0.75 | ARG1 (0.47) | ALOX15SMN1; SMN2MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376649-B1 | REACTING A N-TERMINALLY BLOCKED AMINOALDEHYDE WITH AN ISONITRILE AND A CARBOXYLIC ACID TO GIVE AN AMINO-ALPHA-ACYLOXYCARBOXAMIDE; REMOVING THE ACYLOXY GROUP, OR REMOVING THE PROTECTING GROUP GIVE THE DERIVATIVE. | CORVAS INTERNATIONAL, INC. | 2002-04-23 | — | — | US | disclosed |