Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | FPR1 | P21462 | 6/20 | 0.51 |
| ▸ | FPR2 | P25090 | 5/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726321 | 0.91 | KMT2A (0.56) | KMT2ALMNAMAPTFPR1FPR2 | |
| SCHEMBL7730172 | 0.85 | LMNA (0.51) | KMT2ALMNAMAPTFPR1FPR2 | |
| SCHEMBL7724650 | 0.80 | RAB9A (0.49) | KMT2ALMNAMAPTALDH1A1KDM4E | |
| SCHEMBL7725155 | 0.79 | JAK2 (0.47) | KMT2ALMNAMAPTALDH1A1RECQL | |
| SCHEMBL7723640 | 0.78 | ALDH1A1 (0.52) | KMT2ALMNAMAPTALDH1A1RECQL | |
| SCHEMBL7726296 | 0.77 | JAK2 (0.45) | KMT2ALMNAMAPTALDH1A1MEN1 | |
| SCHEMBL7724719 | 0.77 | JAK2 (0.45) | KMT2ALMNAMAPTALDH1A1KDM4E | |
| SCHEMBL7726418 | 0.77 | ALDH1A1 (0.39) | LMNAMAPTALDH1A1RECQLRXFP1 | |
| SCHEMBL7720154 | 0.76 | JAK2 (0.44) | KMT2ALMNAMAPTALDH1A1RECQL | |
| SCHEMBL7726706 | 0.76 | ADORA3 (0.40) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |