Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PTGIR | P43119 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7730177 | 0.83 | L3MBTL1 (0.49) | LMNACRHR1L3MBTL1ALDH1A1RECQL | |
| SCHEMBL7720142 | 0.82 | MAPT (0.55) | LMNAALDH1A1MAPTHDAC1KMT2A | |
| SCHEMBL7726527 | 0.80 | CRHR1 (0.45) | LMNACRHR1L3MBTL1ALDH1A1RECQL | |
| SCHEMBL7724970 | 0.78 | CRHR1 (0.49) | LMNACRHR1L3MBTL1ALDH1A1RECQL | |
| SCHEMBL7723523 | 0.78 | CRHR1 (0.51) | LMNACRHR1L3MBTL1ALDH1A1RECQL | |
| SCHEMBL7720077 | 0.77 | CASP1 (0.48) | LMNACRHR1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL7720163 | 0.77 | L3MBTL1 (0.49) | CRHR1L3MBTL1ALDH1A1MAPTPTGIR | |
| SCHEMBL7723691 | 0.76 | CRHR1 (0.49) | LMNACRHR1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL7723459 | 0.76 | CRHR1 (0.47) | LMNACRHR1RAB9AKMT2ANPC1 | |
| SCHEMBL7726406 | 0.76 | CYP3A4 (0.49) | LMNACRHR1ALDH1A1PTGIRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |