Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HEXA | P06865 | 1/20 | 0.36 |
| ▸ | HEXB | P07686 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584551 | 0.84 | HTR6 (0.41) | HTR6ALDH1A1DRD4DRD2HTR2A | |
| SCHEMBL7737728 | 0.79 | HTR6 (0.45) | HTR6ALDH1A1DRD4DRD2HTR2A | |
| SCHEMBL7358743 | 0.77 | ALDH1A1 (0.61) | ALDH1A1DRD4MEN1KMT2AUSP2 | |
| SCHEMBL7737834 | 0.77 | PTGIR (0.43) | HTR6ALDH1A1DRD2HTR2AMCHR1 | |
| SCHEMBL7737187 | 0.77 | HTR6 (0.41) | HTR6ALDH1A1DRD2HTR2AMCHR1 | |
| SCHEMBL7739689 | 0.74 | ALOX12 (0.40) | HTR6ALDH1A1DRD2HTR2AMCHR1 | |
| SCHEMBL7736480 | 0.74 | ALDH1A1 (0.41) | ALDH1A1CHRM1MEN1KMT2ATSHR | |
| SCHEMBL13545339 | 0.73 | CHRM1 (0.42) | HTR6DRD2HTR2AMCHR1CHRM1 | |
| SCHEMBL7730055 | 0.72 | ALOX12 (0.58) | ALDH1A1MEN1KMT2AGAATP53 | |
| SCHEMBL7729866 | 0.70 | DRD2 (0.38) | DRD4DRD2HTR2AKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1202084-C | Fused benzene heterocycle derivatives and utilization thereof | TORAY INDUSTRIES (JP) | 2005-05-18 | — | — | CN | disclosed |
| US-6407096-B1 | 1,4-BENZOTHIAZINE AND 1,4-BENZOXAZINE DERIVATIVES; HYPOTENSIVE, ANTIISCHEMIC, ANTIALLERGEN, ANTIASTHMATIC AND ANTICOAGULANT AGENTS; CARDIOVASCULAR DISORDERS | TORAY INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| CN-1287553-A | Fused benzene heterocycle derivatives and utilization thereof | TORAY INDUSTRIES (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1028113-A1 | FUSED BENZENE HETEROCYCLE DERIVATIVES AND UTILIZATION THEREOF | TORAY INDUSTRIES, INC. (JP) | 2000-08-16 | — | — | EP | disclosed |