Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 10/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017476 | 0.68 | HTR2C (0.41) | HTR6CYP2C19HTR2AHTR2CHTR2B | |
| SCHEMBL15728642 | 0.67 | HTR4 (0.47) | MAPTGAAALDH1A1HTT | |
| SCHEMBL15210114 | 0.67 | PKM (0.40) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL23908182 | 0.66 | MEN1 (0.51) | HTR6MAPTNPSR1POLBLMNA | |
| SCHEMBL6935744 | 0.66 | HTR1A (0.36) | MAPTNPSR1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL11695821 | 0.66 | KAT2B (0.61) | MAPTLMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL5915126 | 0.66 | DRD2 (0.51) | HTR6MAPTLMNACYP2C19HTR2A | |
| SCHEMBL6474943 | 0.65 | HTR1A (0.59) | LMNA | |
| SCHEMBL9527372 | 0.64 | HTR2C (0.46) | HTR6MAPTLMNACYP2C19HTR2A | |
| SCHEMBL6038195 | 0.64 | MAPT (0.69) | MAPTPOLBLMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399614-B1 | TREATING NEUROMUSCULAR DYSFUNCTION OF LOWER URINARY TRACT VIA PERIPHERAL OR CENTRAL NERVOUS SYSTEM; SEROTONIN RECEPTOR ANTAGONIST | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-06-04 | — | — | US | disclosed |