Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | DUT | P33316 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9091856 | 0.78 | HTR1D (0.43) | HTR1DKDM4EADRB2LMNAHTR6 | |
| SCHEMBL9093086 | 0.77 | HTR1D (0.42) | HTR1DADRB2HTR6DUTSLC6A4 | |
| SCHEMBL7734107 | 0.76 | ICMT (0.50) | HTR1DKDM4EALDH1A1ADRB2LMNA | |
| SCHEMBL7734844 | 0.75 | KDM4E (0.51) | HTR1DKDM4EALDH1A1ADRB2LMNA | |
| SCHEMBL7723955 | 0.75 | KDM4E (0.48) | HTR1DKDM4EALDH1A1ADRB2LMNA | |
| SCHEMBL5241306 | 0.75 | ADRB2 (0.54) | HTR1DKDM4EALDH1A1ADRB2LMNA | |
| SCHEMBL7733863 | 0.75 | MPO (0.56) | SLC6A4KMT2A | |
| SCHEMBL17979880 | 0.75 | DUT (0.36) | DUTCNR1 | |
| SCHEMBL30817963 | 0.75 | DUT (0.36) | DUTCNR1 | |
| SCHEMBL5239371 | 0.74 | ADRB2 (0.52) | HTR1DKDM4EALDH1A1ADRB2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828325-B2 | A benzoxazolopiperazine derivative useful for treating Parkinson's diseases, schizophrenia, anxiety and depression | SOLVAY PHARMACEUTICALS B.V. (CH) | 2004-12-07 | — | — | US | disclosed |