SCHEMBL7735579

SCHEMBL7735579

NCCC[C@@H](N)C(=O)N[C@H](CCc1ccccc1)C(O)c1nc2ccccc2[nH]1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
IDO1 P14902 1/20 0.43
ALOX12 P18054 1/20 0.42
ALDH1A1 P00352 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
PIN1 Q13526 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL7734124 0.95 CYP1A2 (0.42) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL7734127 0.83 CYP3A4 (0.38) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL7723353 0.78 HDAC3 (0.56) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Trifluoroacetic Acid SCHEMBL7731111 0.75 MMP2 (0.38) HDAC3HDAC4HDAC1HDAC7HDAC2
Trifluoroacetic Acid SCHEMBL7723157 0.75 HPGD (0.39) CYP1A2CYP2C9CYP2C19HDAC3HDAC4
SCHEMBL6063677 0.74 ALOX12 (0.46) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL7730106 0.74 CTSC (0.38) MMP2ERAP2ERAP1LNPEP
SCHEMBL1246343 0.73 LNPEP (0.55) MMP2ERAP2ERAP1LNPEP
SCHEMBL7857980 0.73 LNPEP (0.55) MMP2ERAP2ERAP1LNPEP
SCHEMBL7732452 0.73 LMNA (0.42) HDAC1HDAC8KMT2AMMP2ERAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6436980-B1 TRANSPORT PROTEIN SUPPRESSORS; MICROBIOCIDES ESSENTIAL THERAPEUTICS, INC. 2002-08-20 US disclosed