Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NOS2 | P35228 | 3/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL597287 | 0.88 | FFAR4 (0.44) | ALDH1A1TSHRNOS2NOS3NOS1 | |
| SCHEMBL10492672 | 0.85 | CNR1 (0.38) | ALDH1A1TSHRNOS2NOS3NOS1 | |
| SCHEMBL4575378 | 0.85 | CNR1 (0.38) | ALDH1A1TSHRNOS2NOS3NOS1 | |
| SCHEMBL10775544 | 0.84 | PTGS2 (0.50) | ALDH1A1TSHRKDM4ESKP2NPC1 | |
| SCHEMBL16962402 | 0.83 | FFAR4 (0.44) | ALDH1A1NOS2NOS3NOS1FFAR4 | |
| SCHEMBL23562 | 0.81 | ALDH1A1 (0.60) | ALDH1A1TSHRNOS2NOS3NOS1 | |
| SCHEMBL27667787 | 0.80 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ECNR1MAPT | |
| SCHEMBL5568680 | 0.79 | FFAR4 (0.40) | ALDH1A1TSHRNOS2NOS3NOS1 | |
| SCHEMBL14088678 | 0.78 | ALDH1A1 (0.63) | ALDH1A1TSHRNOS2NOS3NOS1 | |
| SCHEMBL26431093 | 0.78 | ALDH1A1 (0.44) | ALDH1A1TSHRNOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021156170-A1 | ANTIBODIES AGAINST KLK5 | UCB Biopharma SRL (BE) | 2021-08-12 | — | — | WO | disclosed |
| US-9328071-B2 | Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals | SANOFI (FR) | 2016-05-03 | — | — | US | disclosed |
| US-8932842-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-8932842-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140309264-A1 | ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2014-10-16 | — | — | US | disclosed |
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
| US-8278084-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2012-10-02 | — | — | US | disclosed |
| EP-2292592-B1 | SULFONAMIDE COMPOUND AND APPLICATION THEREOF | ASAHI KASEI PHARMA CORP (JP) | 2012-09-05 | — | — | EP | disclosed |
| US-20100203613-A1 | Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-12 | — | — | US | disclosed |
| EP-0051805-B1 | PROCESS FOR THE PREPARATION OF AROMATIC AMINES | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-01-18 | — | — | EP | disclosed |
| US-4375561-A | Process for the preparation of aromatic amines | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-03-01 | — | — | US | disclosed |
| EP-0051805-A1 | Process for the preparation of aromatic amines | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-05-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NOS2, NOS1, NOS3 | ALDH1A1 1362/4885TSHR 4480/4885NOS2 1/4885 |
| US-20100203613-A1 | Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition | NOS2, NOS1, NOS3 | ALDH1A1 1362/4885TSHR 4480/4885NOS2 1/4885 |
| US-20140309264-A1 | ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | EDF1, LPAR2, LIPG | ALDH1A1 2149/4885TSHR 2416/4885NOS2 1358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.