Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NOS3 | P29474 | 3/20 | 0.40 |
| ▸ | NOS2 | P35228 | 3/20 | 0.40 |
| ▸ | HEXA | P06865 | 1/20 | 0.36 |
| ▸ | HEXB | P07686 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL271754 | 0.87 | ALDH1A1 (0.42) | ALDH1A1TSHRNOS3NOS2PTGS2 | |
| SCHEMBL397098 | 0.84 | NOS3 (0.41) | ALDH1A1TSHRNOS3NOS2NOS1 | |
| SCHEMBL7042571 | 0.84 | NOS3 (0.41) | ALDH1A1TSHRNOS3NOS2NOS1 | |
| SCHEMBL14088678 | 0.82 | ALDH1A1 (0.63) | ALDH1A1TSHRNOS3NOS2NOS1 | |
| SCHEMBL7737459 | 0.81 | ALDH1A1 (0.55) | ALDH1A1TSHRNOS3NOS2NOS1 | |
| SCHEMBL168174 | 0.81 | PGK1 (0.44) | ALDH1A1TSHRNOS3NOS2NOS1 | |
| SCHEMBL5490825 | 0.81 | PGK1 (0.44) | ALDH1A1TSHRNOS3NOS2NOS1 | |
| SCHEMBL31686189 | 0.80 | ALDH1A1 (0.60) | ALDH1A1TSHRNOS2PGK1PGK2 | |
| SCHEMBL22700417 | 0.80 | ALDH1A1 (0.60) | ALDH1A1TSHRNOS2PGK1PGK2 | |
| Nitrogen SCHEMBL28571594 | 0.79 | NOS3 (0.38) | ALDH1A1TSHRNOS3NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12459925-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NodThera Limited (GB) | 2025-11-04 | — | — | US | disclosed |
| EP-3728238-B1 | SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS | NODTHERA LTD (GB) | 2025-06-18 | — | — | EP | disclosed |
| US-20240368129-A1 | SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS | NodThera Limited (GB) | 2024-11-07 | — | — | US | disclosed |
| US-12012397-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NodThera Limited (GB) | 2024-06-18 | — | — | US | disclosed |
| US-20230158005-A1 | Substituted Azole Dione Compounds with Antiviral Activity | STEMLINE THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230145050-A1 | SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS | NodThera Limited (GB) | 2023-05-11 | — | — | US | disclosed |
| US-20230075221-A1 | SUBSTITUTED 1,2,4-TRIAZOLO[4,3-A]PYRIDINE DERIVATIVE AND PREPARATION METHOD, HERBICIDAL COMPOSITION AND APPLICATION THEREOF | QINGDAO KINGAGROOT CHEMICAL COMPOUND CO., LTD. (CN) | 2023-03-09 | — | — | US | disclosed |
| US-11518757-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NodThera Limited (GB) | 2022-12-06 | — | — | US | disclosed |
| WO-2022232320-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-11-03 | — | — | WO | disclosed |
| EP-3950357-A1 | INKJET INK FOR INFRARED ABSORBENT IMAGE FORMATION, METHOD FOR INFRARED ABSORBENT IMAGE FORMATION, AND RECORDING MATERIAL | FUJIFILM Corporation (JP) | 2022-02-09 | — | — | EP | disclosed |
| EP-0437105-B1 | Intermediates and colorants having primary hydroxyl enriched poly(oxyalkylene) moieties and their preparation | MILLIKEN RES CORP (US) | 1996-11-13 | — | — | EP | disclosed |
| EP-0437105-A1 | Intermediates and colorants having primary hydroxyl enriched poly(oxyalkylene) moieties and their preparation | MILLIKEN RESEARCH CORPORATION (US) | 1991-07-17 | — | — | EP | disclosed |
| US-4721721-A | 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses | RORER PHARMACEUTICAL CORPORATION (US) | 1988-01-26 | — | — | US | disclosed |
| EP-0207140-A4 | BICYCLIC HETEROARYL THIAZOLE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES. | RORER INTERNAT OVERSEAS INC (US) | 1987-06-15 | — | — | EP | disclosed |
| EP-0207140-A1 | BICYCLIC HETEROARYL THIAZOLE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1987-01-07 | — | — | EP | disclosed |
| WO-1986003749-A1 | BICYCLIC HETEROARYL THIAZOLE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1986-07-03 | — | — | WO | disclosed |
| EP-0019158-B1 | PROCESS FOR THE PRODUCTION OF M-SUBSTITUTED N-METHYLANILINES | BASF Aktiengesellschaft (DE) | 1982-09-15 | — | — | EP | disclosed |
| EP-0019158-A1 | Process for the production of m-substituted N-methylanilines | BASF Aktiengesellschaft (DE) | 1980-11-26 | — | — | EP | disclosed |
| US-4196142-A | 2-Chloro-n-isopropyl-3,5-disubstituted or 3,4,5-trisubstitutes lower alkyl acetanilides as herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1980-04-01 | — | — | US | disclosed |
| US-4147804-A | ANTIARRHYTHMIA AGENTS | WILLIAM H. RORER, INC. (US) | 1979-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12012397-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NLRP3, NOD1, IL1B | ALDH1A1 612/4885TSHR 4648/4885NOS3 351/4885 |
| US-20230145050-A1 | SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS | NLRP3, NOD1, IL1B | ALDH1A1 612/4885TSHR 4648/4885NOS3 351/4885 |
| US-20240368129-A1 | SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS | NLRP3, NOD1, IL1B | ALDH1A1 612/4885TSHR 4648/4885NOS3 351/4885 |
| US-20230075221-A1 | SUBSTITUTED 1,2,4-TRIAZOLO[4,3-A]PYRIDINE DERIVATIVE AND PREPARATION METHOD, HERBICIDAL COMPOSITION AND APPLICATION THEREOF | TH, CYP4X1, CYP4B1 | ALDH1A1 1179/4885TSHR 458/4885NOS3 299/4885 |
| US-11518757-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NLRP3, NOD1, IL1B | ALDH1A1 612/4885TSHR 4648/4885NOS3 351/4885 |
| US-20230158005-A1 | Substituted Azole Dione Compounds with Antiviral Activity | MAVS, DDX18, ZC3HAV1 | ALDH1A1 1388/4885TSHR 4570/4885NOS3 1115/4885 |
| US-12459925-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NLRP3, NOD1, IL1B | ALDH1A1 612/4885TSHR 4648/4885NOS3 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.