Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732564 | 0.66 | ABCG2 (0.52) | SMN1; SMN2CSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL14917577 | 0.65 | SMN1; SMN2 (0.62) | SMN1; SMN2ADORA1PARP1CAPN1DAO | |
| SCHEMBL1287276 | 0.63 | SMN1; SMN2 (0.69) | SMN1; SMN2ADORA1PARP1DAOTP53 | |
| Dimethylamine SCHEMBL27691701 | 0.63 | SMN1; SMN2 (0.63) | SMN1; SMN2ADORA1PARP1DAOTP53 | |
| SCHEMBL9286770 | 0.63 | PARP1 (0.51) | SMN1; SMN2ADORA1PARP1CAPN1DAO | |
| SCHEMBL8019571 | 0.62 | GRM5 (0.58) | SMN1; SMN2GRM5HPGDKDM4ENPC1 | |
| SCHEMBL1699487 | 0.62 | ACHE (0.57) | GRM5CSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL9286766 | 0.61 | PARP1 (0.49) | SMN1; SMN2ADORA1PARP1CAPN1DAO | |
| Benzylthiouracil SCHEMBL815137 | 0.61 | SMN1; SMN2 (1.00) | SMN1; SMN2ADORA1PARP1DAOHPGD | |
| SCHEMBL7106470 | 0.61 | PARP1 (0.65) | SMN1; SMN2ADORA1PARP1CAPN1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071661-A4 | PROCESS FOR PREPARING 4-HYDROXY INDOLE, INDAZOLE AND CARBAZOLE COMPOUNDS | LILLY CO ELI (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-1071661-A1 | PROCESS FOR PREPARING 4-HYDROXY INDOLE, INDAZOLE AND CARBAZOLE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999054295-A1 | PROCESS FOR PREPARING 4-HYDROXY INDOLE, INDAZOLE AND CARBAZOLE COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-10-28 | — | — | WO | disclosed |