Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 18/20 | 0.38 |
| ▸ | NOS3 | P29474 | 16/20 | 0.38 |
| ▸ | NOS2 | P35228 | 16/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740427 | 0.85 | NOS1 (0.38) | NOS1NOS3NOS2 | |
| SCHEMBL7740469 | 0.80 | HDAC6 (0.34) | HDAC10HDAC6CA12CA1CA2 | |
| SCHEMBL7738859 | 0.75 | HDAC6 (0.36) | HDAC10HDAC6CA12CA1CA2 | |
| SCHEMBL7734201 | 0.69 | SYK (0.33) | NOS1NOS3NOS2CA12CA1 | |
| SCHEMBL7742144 | 0.66 | NOS1 (0.42) | NOS1NOS3NOS2 | |
| SCHEMBL7734258 | 0.66 | TDO2 (0.35) | — | |
| SCHEMBL7740426 | 0.66 | PDK1 (0.40) | HDAC10HDAC6CA12CA1CA2 | |
| SCHEMBL7740424 | 0.65 | MEN1 (0.36) | HDAC10HDAC6 | |
| SCHEMBL29971591 | 0.64 | CA12 (0.38) | HDAC10HDAC6CA12CA1CA2 | |
| SCHEMBL18805717 | 0.64 | CA12 (0.38) | HDAC10HDAC6CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |