Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 6/20 | 0.40 |
| ▸ | CA2 | P00918 | 6/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394733 | 0.96 | HDAC1 (0.58) | HDAC1HDAC6P4HTMKDM4EKMT2A | |
| SCHEMBL4400941 | 0.80 | HDAC1 (0.64) | HDAC1HDAC6KDM4EKMT2AKCNQ3 | |
| SCHEMBL30544993 | 0.78 | HDAC1 (0.62) | HDAC1HDAC6P4HTMKDM4EMAPT | |
| SCHEMBL575041 | 0.78 | HDAC1 (0.62) | HDAC1HDAC6KDM4EKMT2AKCNQ3 | |
| Potassium Ion SCHEMBL28488734 | 0.78 | P4HTM (0.76) | P4HTMCA1CA2NPC1 | |
| SCHEMBL181465 | 0.78 | HDAC1 (0.62) | HDAC1HDAC6P4HTMKDM4EMAPT | |
| SCHEMBL31290288 | 0.78 | HDAC1 (0.62) | HDAC1HDAC6KDM4EKMT2AKCNQ3 | |
| Pyridine-2,5-Dicarboxylic Acid SCHEMBL25439990 | 0.77 | P4HTM (0.53) | P4HTMKDM4ECA1CA2NPC1 | |
| SCHEMBL600144 | 0.77 | HDAC1 (0.60) | HDAC1HDAC6KDM4EKMT2AKCNQ3 | |
| SCHEMBL2488844 | 0.77 | HDAC1 (0.60) | HDAC1HDAC6P4HTMKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001029003-A1 | PROCESS FOR THE PREPARATION OF 1-(6-METHYLPYRIDIN-3-YL)-2-(4-METHYLTHIOPHENYL)-ETHANONE AND ITS USE IN THE SYNTHESIS OF DIARYLPYRIDINES | ZAMBON GROUP S.P.A. (IT) | 2001-04-26 | — | — | WO | disclosed |